SidaGhanaV1, Main, Exploration, bibRecord, 000877

Hepatitis B virus and sexual behavior in Rakai, Uganda

Identifieur interne : 000877 ( Main/Exploration ); précédent : 000876; suivant : 000878

Hepatitis B virus and sexual behavior in Rakai, Uganda

Auteurs : Lara Stabinski [États-Unis] ; Steven J. Reynolds [États-Unis] ; Ponsiano Ocama [Ouganda] ; Oliver Laeyendecker [États-Unis] ; David Serwadda [Ouganda] ; Ron H. Gray [Ouganda, États-Unis] ; Maria Wawer [Ouganda, États-Unis] ; David L. Thomas [États-Unis] ; Thomas C. Quinn [États-Unis] ; Gregory D. Kirk [États-Unis]

Source :

Journal of Medical Virology [ 0146-6615 ] ; 2011-05.

RBID : ISTEX:7C0F2E61DECCB845966A08A2ED637D4CD6A456DA

Descripteurs français

Wicri :
- geographic : Ouganda.
- topic : épidémiologie, Santé publique, Vaccination.

English descriptors

Abstract

HIV and hepatitis B virus (HBV) co‐infection poses important public health considerations in resource‐limited settings. Demographic data and sera from adult participants of the Rakai Health Sciences Program Cohort in Southwestern Uganda were examined to determine HBV seroprevalence patterns in this area of high HIV endemicity prior to the introduction of anti‐retroviral therapy. Commercially available EIAs were used to detect prevalent HBV infection (positive for HBV core antibody [anti‐HBc] and/or positive HBV surface antigen [HBsAg]), and chronic infection (positive for HBsAg). Of 438 participants, 181 (41%) had prevalent HBV infection while 21 (5%) were infected chronically. Fourteen percent of participants were infected with HIV. Fifty three percent showed evidence of prevalent HBV infection compared to 40% among participants infected with HIV (P = 0.067). Seven percent of participants infected with HIV were HBsAg positive compared to 4% among participants not infected with HIV (P = 0.403). The prevalence of prevalent HBV infection was 55% in adults aged >50 years old, and 11% in persons under 20 years. In multivariable analysis, older age, HIV status, and serologic syphilis were significantly associated with prevalent HBV infection. Transfusion status and receipt of injections were not significantly associated with HBV infection. Contrary to expectations that HBV exposure in Uganda occurred chiefly during childhood, prevalent HBV infection was found to increase with age and was associated sexually transmitted diseases (HIV and syphilis.) Therefore vaccination against HBV, particularly susceptible adults with HIV or at risk of HIV/STDs should be a priority. J. Med. Virol. 83:796–800, 2011. © 2011 Wiley‐Liss, Inc.

Url:

https://api.istex.fr/document/7C0F2E61DECCB845966A08A2ED637D4CD6A456DA/fulltext/pdf

DOI: 10.1002/jmv.22051

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Istex, to step Corpus: 000720
to stream Istex, to step Curation: 000720
to stream Istex, to step Checkpoint: 000099
to stream Main, to step Merge: 000880
to stream Main, to step Curation: 000877

Le document en format XML

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<author><name sortKey="Stabinski, Lara" sort="Stabinski, Lara" uniqKey="Stabinski L" first="Lara" last="Stabinski">Lara Stabinski</name>
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<author><name sortKey="Reynolds, Steven J" sort="Reynolds, Steven J" uniqKey="Reynolds S" first="Steven J." last="Reynolds">Steven J. Reynolds</name>
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<author><name sortKey="Gray, Ron H" sort="Gray, Ron H" uniqKey="Gray R" first="Ron H." last="Gray">Ron H. Gray</name>
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<author><name sortKey="Wawer, Maria" sort="Wawer, Maria" uniqKey="Wawer M" first="Maria" last="Wawer">Maria Wawer</name>
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<author><name sortKey="Thomas, David L" sort="Thomas, David L" uniqKey="Thomas D" first="David L." last="Thomas">David L. Thomas</name>
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<author><name sortKey="Quinn, Thomas C" sort="Quinn, Thomas C" uniqKey="Quinn T" first="Thomas C." last="Quinn">Thomas C. Quinn</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult population</term>
<term>African countries</term>
<term>Blood transfusions</term>
<term>Bloomberg school</term>
<term>Chronic infection</term>
<term>Dual therapy</term>
<term>Epidemiology</term>
<term>Hbsag</term>
<term>Hbsag positivity</term>
<term>Hepatitis</term>
<term>High prevalence</term>
<term>Higher risk</term>
<term>Infection</term>
<term>Infectious diseases</term>
<term>Intramural research</term>
<term>Johns hopkins university</term>
<term>Johns hopkins university school</term>
<term>Liver disease</term>
<term>Makerere university</term>
<term>Male gender</term>
<term>Medical injections</term>
<term>Multivariate model</term>
<term>National institute</term>
<term>National institutes</term>
<term>Natural history</term>
<term>Nontreponemal screening test</term>
<term>Participant</term>
<term>Prevalence</term>
<term>Public health</term>
<term>Questionnaire data</term>
<term>Rakai</term>
<term>Rakai health sciences program</term>
<term>Random sample</term>
<term>Regional variation</term>
<term>Risk factors</term>
<term>Serologic syphilis</term>
<term>Sexual transmission</term>
<term>Southwestern uganda</term>
<term>Study participants</term>
<term>Study population</term>
<term>Surface antigen</term>
<term>Syphilis</term>
<term>Transfusion</term>
<term>Transmission patterns</term>
<term>Treatment strategies</term>
<term>Uganda</term>
<term>Unheated serum test</term>
<term>Univariate</term>
<term>Univariate analysis</term>
<term>Vaccination</term>
<term>Viral hepatitis</term>
<term>Virol</term>
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<keywords scheme="Teeft" xml:lang="en"><term>Adult population</term>
<term>African countries</term>
<term>Blood transfusions</term>
<term>Bloomberg school</term>
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<term>Dual therapy</term>
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<term>Hbsag</term>
<term>Hbsag positivity</term>
<term>Hepatitis</term>
<term>High prevalence</term>
<term>Higher risk</term>
<term>Infection</term>
<term>Infectious diseases</term>
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<term>Johns hopkins university</term>
<term>Johns hopkins university school</term>
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<term>Male gender</term>
<term>Medical injections</term>
<term>Multivariate model</term>
<term>National institute</term>
<term>National institutes</term>
<term>Natural history</term>
<term>Nontreponemal screening test</term>
<term>Participant</term>
<term>Prevalence</term>
<term>Public health</term>
<term>Questionnaire data</term>
<term>Rakai</term>
<term>Rakai health sciences program</term>
<term>Random sample</term>
<term>Regional variation</term>
<term>Risk factors</term>
<term>Serologic syphilis</term>
<term>Sexual transmission</term>
<term>Southwestern uganda</term>
<term>Study participants</term>
<term>Study population</term>
<term>Surface antigen</term>
<term>Syphilis</term>
<term>Transfusion</term>
<term>Transmission patterns</term>
<term>Treatment strategies</term>
<term>Uganda</term>
<term>Unheated serum test</term>
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<front><div type="abstract" xml:lang="en">HIV and hepatitis B virus (HBV) co‐infection poses important public health considerations in resource‐limited settings. Demographic data and sera from adult participants of the Rakai Health Sciences Program Cohort in Southwestern Uganda were examined to determine HBV seroprevalence patterns in this area of high HIV endemicity prior to the introduction of anti‐retroviral therapy. Commercially available EIAs were used to detect prevalent HBV infection (positive for HBV core antibody [anti‐HBc] and/or positive HBV surface antigen [HBsAg]), and chronic infection (positive for HBsAg). Of 438 participants, 181 (41%) had prevalent HBV infection while 21 (5%) were infected chronically. Fourteen percent of participants were infected with HIV. Fifty three percent showed evidence of prevalent HBV infection compared to 40% among participants infected with HIV (P = 0.067). Seven percent of participants infected with HIV were HBsAg positive compared to 4% among participants not infected with HIV (P = 0.403). The prevalence of prevalent HBV infection was 55% in adults aged >50 years old, and 11% in persons under 20 years. In multivariable analysis, older age, HIV status, and serologic syphilis were significantly associated with prevalent HBV infection. Transfusion status and receipt of injections were not significantly associated with HBV infection. Contrary to expectations that HBV exposure in Uganda occurred chiefly during childhood, prevalent HBV infection was found to increase with age and was associated sexually transmitted diseases (HIV and syphilis.) Therefore vaccination against HBV, particularly susceptible adults with HIV or at risk of HIV/STDs should be a priority. J. Med. Virol. 83:796–800, 2011. © 2011 Wiley‐Liss, Inc.</div>
</front>
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<name sortKey="Quinn, Thomas C" sort="Quinn, Thomas C" uniqKey="Quinn T" first="Thomas C." last="Quinn">Thomas C. Quinn</name>
<name sortKey="Quinn, Thomas C" sort="Quinn, Thomas C" uniqKey="Quinn T" first="Thomas C." last="Quinn">Thomas C. Quinn</name>
<name sortKey="Reynolds, Steven J" sort="Reynolds, Steven J" uniqKey="Reynolds S" first="Steven J." last="Reynolds">Steven J. Reynolds</name>
<name sortKey="Reynolds, Steven J" sort="Reynolds, Steven J" uniqKey="Reynolds S" first="Steven J." last="Reynolds">Steven J. Reynolds</name>
<name sortKey="Thomas, David L" sort="Thomas, David L" uniqKey="Thomas D" first="David L." last="Thomas">David L. Thomas</name>
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<country name="Ouganda"><noRegion><name sortKey="Ocama, Ponsiano" sort="Ocama, Ponsiano" uniqKey="Ocama P" first="Ponsiano" last="Ocama">Ponsiano Ocama</name>
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Le SIDA au Ghana (serveur d'exploration)

Hepatitis B virus and sexual behavior in Rakai, Uganda

Hepatitis B virus and sexual behavior in Rakai, Uganda

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri